The Intake of Aronia Melanocarpa Fruits and Juice has Great Potential for Prevention of Socially Significant Diseases

Socially significant diseases are preceded by changes in metabolism, oxidative stress and changes in the vascular wall of the arteries leading to poor blood supply to the organs, insufficient oxygen to the organs or thrombosis. Prevention of these diseases involves clarifying genetic predispositions and changing lifestyles (diet and physical activity). Nutrition is a major social problem in the presence of a lot of aggression in the food industry and the supply of very low-quality food. The homeland of Aronia bushes is North America. The fruits of this plant have been known for their medicinal properties since ancient times. Today, we rediscover this fruit as a true, useful food, which has, so far, been only incidentally sought in states of disease coming close to the incurable ones. The current research points to the necessity of including this food in our daily diet as a grace to the healthy lifestyle. Epidemiological studies and associated meta-analyses strongly suggest that long-term diets rich in plant polyphenols offer protection against development of cancers, cardiovascular disease, diabetes, osteoporosis and neurodegenerative diseases. The aronia fruit can be consumed as fresh fruit, cold pressed juice from fresh fruits or the so-called “fruit” wine, dried (in the form of flour) or frozen [1,2].


Introduction
Socially significant diseases are preceded by changes in metabolism, oxidative stress and changes in the vascular wall of the arteries leading to poor blood supply to the organs, insufficient oxygen to the organs or thrombosis. Prevention of these diseases involves clarifying genetic predispositions and changing lifestyles (diet and physical activity). Nutrition is a major social problem in the presence of a lot of aggression in the food industry and the supply of very low-quality food. The homeland of Aronia bushes is North America. The fruits of this plant have been known for their medicinal properties since ancient times. Today, we rediscover this fruit as a true, useful food, which has, so far, been only incidentally sought in states of disease coming close to the incurable ones. The current research points to the necessity of including this food in our daily diet as a grace to the healthy lifestyle. Epidemiological studies and associated meta-analyses strongly suggest that long-term diets rich in plant polyphenols offer protection against development of cancers, cardiovascular disease, diabetes, osteoporosis and neurodegenerative diseases. The aronia fruit can be consumed as fresh fruit, cold pressed juice from fresh fruits or the so-called "fruit" wine, dried (in the form of flour) or frozen [1,2]. Each compound demonstrated potent hydroxyl radical scavenging activity, moderate quinone reductase-inducing activity, and no notable cytotoxicity to murine hepa1c1c7 cells in vitro. These non-crystalline molecules were isolated from aronia melanocarpa and significant challenges in their structural determination were overcome using computer-assisted structure elucidation software

Considerable influence on erythrocyte membrane and hemoglobin
function is discussed due to the proven antioxidant effects of the polyphenols contained in the fruits of the melanocarpa aronia and the rich content of minerals, vitamins and trace elements [11][12][13][14][15].
Aronia berries have a beneficial effect on liver fibrosis. The recovery from liver fibrosis is associated with expression levels of Gadd45g and Igfbp1 in the liver. The beneficial effects of aronia berries on liver fibrosis reduce the risk of liver cancer diseases and insulin resistance, resulting in reduction of serum FABP1 and FABP4 levels.
Аronia berries inhibit ACE activity in the kidney and reduction of ACE activity in the local renin-angiotensin system. Aronia berries may also become a useful drug for the prevention of hypotension [11,19]. A multifaceted healing effect has been manifested with models of diseases after the course of aronia juice intake, for instance: a general anti-inflammatory effect, regardless of the process localization; an antimutagenic effect; facilitating heart activity by stabilizing the heart muscle, the circulation system g) It has been established that aronia products reduce thrombocyte aggregation and prevent thrombi formation in the arteries.
Last, but not least, we should mention the favorable neuropsychological effects experienced by subjects in the groups under study [20][21][22][23][24]. Clinical investigations with people are a bit more