Endoscopic Myotomy: Advancements in Foregut Endoscopy

The emerging field of endoscopic surgery can now be used to treat many diseases of the foregut which were earlier treated surgically. It is less invasive thereby having the advantages of decreased pain, length of hospital stays and earlier recovery as compared to the traditional surgical procedures. Recent advances like per oral endoscopic myotomy (POEM) have made long term outcomes comparable, if not better, as compared to surgical procedures in the treatment of achalasia [1]. This article will review the recent advances in foregut endoscopy especially with reference to endoscopic myotomy.


Introduction
The emerging field of endoscopic surgery can now be used to treat many diseases of the foregut which were earlier treated surgically. It is less invasive thereby having the advantages of decreased pain, length of hospital stays and earlier recovery as compared to the traditional surgical procedures. Recent advances like per oral endoscopic myotomy (POEM) have made long term outcomes comparable, if not better, as compared to surgical procedures in the treatment of achalasia [1]. This article will review the recent advances in foregut endoscopy especially with reference to endoscopic myotomy.

Per oral endoscopic Myotomy (POEM)
Esophageal motor disorders, in particular achalasia, have traditionally employed surgical myotomy (Heller). The endoscopic approach, called POEM, is now increasingly being used in achalasia.
POEM involves making an incision in the mucosa after raising a submucosal bleb with saline and indigo carmine or methylene blue solution (Figure 1). A two-centimeter longitudinal incision is made on the mucosa to expose the submucosa using a through-the-scope knife which allows for simultaneous cutting, coagulation and injection. Once the submucosa is exposed, further dissection and injection allows for creation of a tunnel. This is generally started 10 cm above the lower esophageal sphincter (LES) and continued 2 cm beyond the LES. Once the tunnel is completed, selective cutting of the inner circular muscle is performed. Bleeding is often encountered and controlled using coagulation current. Closure of the mucosal incision can be done using endoluminal suturing devices (eg. Apollo Overstitch) or clips.
Achalasia: Standard POEM technique is suited for type I and type II achalasia. POEM can also deliver a longer incision compared to myotomy and hence is the preferred procedure for Achalasia type III. A meta-analysis of 22 studies comparing POEM and laparoscopic Heller myotomy (LHM) showed that POEM was more likely to be successful for type I and type III while the likelihood of success of POEM was similar to LHM for type II [2]. Another study showed that with fewer adverse events including lower risk of mucosotomy and shorter incision closure time [4] while another trial of 63 patients found no difference in short-term treatment efficacy, manometry outcomes, and adverse events [5]. Another difference in approach is the selective myotomy of inner circular bundles compared to full thickness myotomy. A study of 234 patients found comparable short term clinical outcomes but long term outcomes are awaited [6]. However, we prefer selective circular myotomy compared to full thickness myotomy to avoid entering the pleural space and the consequent increase in morbidity.
Clinical success is defined as a post-intervention Eckardt score of 3 or lower or a reduction of LES by 50% or more. In a metaanalysis of 7000 patients, POEM was more effective than LHM in improving dysphagia at 12-, 24-, 30-and 60-month intervals although POEM had higher incidence of reflux [1]. Newer suggested anti-reflux measures include combining POEM with transoral incisional fundoplication with one small study showing improved symptoms of esophagitis and lower need for long term proton pump inhibitor use [7].

Spastic Esophageal Disorders (SED)
This group comprises of diffuse esophageal spasm, nutcracker esophagus, hypercontractile (jackhammer) esophagus and spastic achalasia (Type III). Spastic achalasia and diffuse esophageal spasm have loss of neural inhibition, while jackhammer esophagus is believed to be caused by hypercontractility secondary to cholinergic pathway activation [8]. Medical management is reported to have failure rate of upto 74% in one study [9]. Access to the esophagus surgically may need access to the thorax and abdominal compartments. In LHM, access to the upper esophageal body may be challenging or limited. On the other hand, endoscopy has easy access to the entire esophageal body; therefore, allowing for an extended myotomy with precision. POEM, which was being

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Copy@ Marc F Catalano performed for spastic achalasia, is now being indicated for spastic esophageal disorders. Myotomy is performed in areas of spastic esophageal contractions in the body of the esophagus as well as the lower esophageal sphincter. One meta-analysis showed POEM having a cumulative clinical success rate of 87% with a follow-up ranging from 3 months to 3 years, and also appeared to be effective in 6 patients who had symptom relapse after a prior Heller myotomy. Standardization of techniques of POEM for SEDs including the length of myotomy, approach (anterior, posterior, or both) may help to improve outcomes [10].

Esophagogastric junction outflow obstruction (EGJOO)
EGJOO is a new entity with little known about its etiology. The Chicago classification defined EGJOO as patients having an elevated median integrated relaxation pressure (IRP) on high resolution manometry with intact or weak peristalsis such that criteria for achalasia are not met [11]. The first step is to identify patients with secondary EGJOO due to mechanical obstruction with the help of barium esophagogram, upper endoscopy with biopsies, endoscopic ultrasound and/or CT chest, and treat them appropriately. The remaining patients fall into the idiopathic group, for whom a timed barium esophagram or EndoFLIP (endoluminal functional lumen imaging probe) is done to see if a true obstruction exists. If these tests confirm obstruction and the patient presents with dysphagia as the major complaint, then this group of patients is treated as a variant of achalasia with botulinum toxin, pneumatic dilation, or surgical myotomy. Other patients with normal values are managed medically with reassurance, calcium channel blockers, proton pump inhibitors and/or with simple esophageal dilation [12]. Richter et al reported good durable five-year symptom improvement with pneumatic dilation as first line treatment in 33 patients [12]. POEM has shown promise, but more data is needed at this time. 43-100%) but symptomatic recurrence can be as high as 19% for surgery, 12.8% for rigid endoscopy and 20% for flexible endoscopy [13].

Zenker Diverticulum
Most of the techniques above involve incising of both the mucosa and muscle under limited visualization with little cue to whether the myotomy is complete. To overcome this, a modified technique called Z-POEM is being used to minimize the risk of mediastinitis or perforation. Mucosal incision is made on the apex of the septum followed by submucosal tunneling on both sides of the septum (esophageal and diverticular side). This allows for precise control of complete myotomy under better visualization. The short tunnel is then closed with mucosal clips [14].

Per oral Pyloromyotomy
Gastroparesis is a motility disorder of delayed gastric emptying often not responding to conventional medical treatments. Various