First Case of Alice in Wonderland-like Seizures in a Mother and her Daughter: A New Sign for a Hereditary Origin?

Visual perceptions began early in kinder garden only in situations when lying down and very tired with closed eyes, never in standing or awake situations. After a while pictures of different parts of the body were present. In these visual perceptions, the other parts of the body were not possible to see because one part of the body imposing so big. Visual perceptions occur most often in relaxed lying conditions. She most often realizes the thumb as much too big. The other body parts were realized as big length and the body form very narrow. It did not happen very often, but these perceptions did not make anxious or nervous in the moment of realization. She also described disturbed perception of time. The daughter has a history of THC drug abuse, opiates and alcohol, and ADHS. These visual impressions were never present after excessive parties with drug abuse. Visual perceptions were found in extreme tired situations. There was no history of migraine but of bipolar-2 disorder personality and generalized anxiety disorder (GAD). The mother has an extreme form of migraine. Short history of the 47 years-old mother


Short history of the 26 years-old daughter
Visual perceptions began early in kinder garden only in situations when lying down and very tired with closed eyes, never in standing or awake situations. After a while pictures of different parts of the body were present. In these visual perceptions, the other parts of the body were not possible to see because one part of the body imposing so big. Visual perceptions occur most often in relaxed lying conditions. She most often realizes the thumb as much too big. The other body parts were realized as big length and the body form very narrow. It did not happen very often, but these perceptions did not make anxious or nervous in the moment of realization. She also described disturbed perception of time. The daughter has a history of THC drug abuse, opiates and alcohol, and ADHS. These visual impressions were never present after excessive parties with drug abuse. Visual perceptions were found in extreme tired situations. There was no history of migraine but of bipolar-2 disorder personality and generalized anxiety disorder (GAD). The mother has an extreme form of migraine.

Short history of the 47 years-old mother
Age of the mother 47. The mother has borderline personality disorder and acute panic disorder. The mother has an extreme form of migraine. AIWS seizures occurred in summer 2014 without occurrence of migraine. The seizures occur, when she is full of fear inducing panic attacks as a result of the visual perceptions she realized. In these moments, she cannot divide reality from seizure perception. Most often she realized her hands too big, like the thumb in the daughter, which show the same localization in the upper extremity. She, also like her daughter, describe disturbed perception of time.

Short history of the father
The father died as the daughter was 13 years old and had a history of drug abuse and schizoaffective disorder.
visual perception of own`s body image with induction of bizarre body illusions [1][2][3]. This entity with disturbed visual perception was described as Alice in Wonderland Syndrome. Todd published his first experience in 1955 and defined its literary name in his publication. Caro Lippman was one of the first authors, who described, in 1952, the syndrome for the first time. Illusionary body perceptions can trigger fear in the patients, sometimes many years in early childhood [4][5][6]. AIWS is most often found in children, but also found in adults and elder patients. The normal development can be influenced in the family and at school [7][8][9][10]. AIWS has been described in various publications in connection with many different infectious diseases such as malaria, zicavirus, varicellainduced optical neuromyelitis, Lyme disease, H1N1 flu infection, and mononucleosis [11][12][13][14].
Moreover, is obvious that all these different diseases do not play a role in finding the true origin of Alice in Wonderland syndrome [15][16][17][18][19][20]. A recent publication pointed out the correlation of visual impairment in perception with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis [21]. Differential diagnosis includes Charles Bonnet Syndrome [22]. AIWS like seizures correlate with migraine [5][6][7][8], epilepsy, acute disseminated encephalomyelitis [9], abuse with LSD or montelukast [10]. AIWS like seizures can therefore occur in drug related settings. In our case, the daughter never had any AIWS-like seizure after intake of drugs in parties.
Furthermore, seizures were present after ventricular shunt surgery in hydrocephalus operation and was described in patients after brain tumor resection like glioblastoma. Another fact is, curiously, that earlier publications describe the aspect of AIWS correlating with sexual abuse. In these publications, two older women aged 57 and 61 years describe their horrifying experiences with sexual abuse with the father and report years after their experience independently of AIWS after many years [17][18][19][20]. These sensitive and curious experience from internet shed light on aspects of sexual abuse by describing the entity many years after the experience of both older women analyzing their experience as children [17][18][19][20].
The hallmark of AIWS could be migraine, like in our case in the mother. The daughter had no migraine and described the seizures more intensively and curious. Individuals with AIWS-like seizures lose sense of time, like in our case in the mother and the daughter.
Time seems to pass too fast. Extreme visual hallucinations were found in a few patients with AIWS; they can visualize things that do not exist and can also realize a disturbed impression of situations and events. Visual perception is distorted, as are acoustic and tactile perception. Verbal auditory misperceptions were also described [15,16]. perceptions. Underlying diseases were present, but only the mother had migraine attacks.
In this familial case report, a genetic origin must be supposed.
Next generation sequencing and mutation analysis and other genetic analysis could help in this way. The contact was made by email from the US to Germany. The daughter contacted the author from Columbus, Ohio (USA) and described the experience the mother and her daughter made in the past with exact descriptions of their visual perceptions in the moments of seizure. Very interesting new aspects are in conclusion the possible hereditary aspect, the presence of a seizure only in lying relaxed condition with closed eyes and that the visual perceptions were not fear triggering in the daughter, but only in the mother. Disturbance of time perception was found in both, in the daughter and the mother, so time perception seems to be a typical part of AIWS-like seizures. This familial case shed light on genetic origin, and this should be underpinned by more similar cases.