Antithyroid Arthritis Syndrome

Antithyroid arthritis syndrome is a rare adverse effect with a series of symptoms of fever, arthralgia, myalgia and arthritis. We report a case of a patient with hyper-thyroidism, who presented with Antithyroid arthritis syndrome after being treated with methiamazole and describe the diagnosis, treatments, follow-up of the case. Our aim is to increase awareness of this uncommon but life-threatening adverse effect when diagnosing patients who develop arthritis after being treated with Antithyroid in clinical practice.


Introduction
Hyperthyroidism is a common disease in the world, antithyroid drugs like me-thiamazole and propylthiouracil are commonly used.
One of the rare side effects of class of this medication is antithyroid arthritis syndrome which has been reported in the case described below

Case Report
A man aged 30 years presented to our hospital with a 4-day history of arthralgia. One month prior, he was diagnosed with hyperthyroidism and was started on me-thiamazole 10mg twice a day along with propranolol 10mg three times per day. This treatment partially alleviated his symptoms until 4 days prior to the aforementioned presentation.
On arriving at our department, he disclosed sharp, constant pain in his hands, shoulders, ankle that worsened with touch and movement 4 days prior, he was dis-continued methiamazole and the pain slightly relieved. He reported that he had no fever, oral ulceration and photosensitivity. Family history was significant for system-ic lupus erythematosus in his aunt, rheumatoid arthritis in and carbimazole. carbimazole is not an active sub-stance, it has to be decarboxylated to methiamazole in the liver. The side effects are rashes, toxic liver diseases, vasculitis, agranulocytosis and antithyroid arthritis syndrome, antithyroid arthritis syndrome is a rare adverse effect. A review noted that adverse effects of methiamazole was lower than propylthiouracil significantly. As for Cooper, side effects of methiamazole are dose-dependent, but there is no relationship for propylthiouracil.
According to literatures, we summarize the antithyroid arthritis syndrome as [1] a patient was diagnosed hyperthyroidism; [2]who developed arthritis after treating with antithyroid drugs; [3] who noted the typical symptom of migratory multi-joint pain, [4]occurred within 2-3 months secondary to the use of antithyroid drugs; [5] the symptoms resolved shortly or relieved after discontinuing drug; [6] No joint deformities remain; [7]No past history of arthritis4-6. Given that the present case developed arthritis 1 month after the patient started receiving methiamazole, we diagnosed Antithyroid arthritis syndrome. Owning to concern for his family history and the results of ANA, anticardiolipin antibody at the early time, systemic lupus erythematosus cannot be completely excluded. He was symptom free while on propylthiouracil and tapering doses of prednisone, and his reexamination revealed negative results of anti-body, including ANA, ANCA, anticardiolipin antibody. we excluded the diagnosis of drug-induced lupus.
Little is known regarding the mechanism of this syndrome, although some re-searchers insisted that the pyrimidine group in antithyroid drugs destroys the structure of DNA, and the mercaptan group serves as happen and induces auto-antibody production, triggering an abnormal immune function [7][8][9].Other researchers claimed that the copper affects glutathione metabolism and induces the release of interleukins when binds to antithyroid drugs, which can cause synovial inflammation [10].
The first step of this syndrome is discontinuing antithyroid drugs, due to the cross activity between different drugs was up to 50% [11][12][13]. In order to moderate the symptoms, non-steroidal anti-inflammatory drugs can be used7,9. It is advisable to consider alternative treatment like radioactive iodine and thyroidectomy.
Our patient was discontinued methiamazole and switched to propylthiouracil, fortunately, he can tolerant propylthiouracil and have no further side effects.

Conclusion
The present case highlights the importance of recognizing antithyroid arthritis syndrome as a side effect of antithyroid medicines. It is essential for clinicians to be aware of this condition.
Once the diagnosis is made, it requires discontinuing the drug which can result the symptom immediately. Under the premise of close observation, propylthiouracil can be considered.

Declaration of Interests
The authors declare that there is no conflict of interests.