Mucormycosis (The Black Fungus)

Mucormycosis (zygomycosis, phycomycosis) is referring to infections caused by diagonal of order Mucorales [1]. While the diagonal of this order usually attack persons susceptible to infection of the nasal mucosa and ketoacidosis, or in conditions of immunosuppression like diabetes, solid organ transplant, severe burns, etc. [1]. Although, fungal infectious agents causing minor or major orbital infections [2]. Also, Mucormycosis, affects the sinuses, the brain and the lungs, immunocompromised individuals, such as cancer patients or people with HIV/AIDS and can be life-threatening in diabetic patients [3]. In the point of view in India about 12,000 cases of black fungus have been recorded [4], most of them among patients recovering from Covid19 [4]. While the risk of death from it is 50%, but Mucormycosis infection is usually rare [4].


Introduction
Mucormycosis (zygomycosis, phycomycosis) is referring to infections caused by diagonal of order Mucorales [1]. While the diagonal of this order usually attack persons susceptible to infection of the nasal mucosa and ketoacidosis, or in conditions of immunosuppression like diabetes, solid organ transplant, severe burns, etc. [1]. Although, fungal infectious agents causing minor or major orbital infections [2]. Also, Mucormycosis, affects the sinuses, the brain and the lungs, immunocompromised individuals, such as cancer patients or people with HIV/AIDS and can be life-threatening in diabetic patients [3]. In the point of view in India about 12,000 cases of black fungus have been recorded [4], most of them among patients recovering from Covid-19 [4]. While the risk of death from it is 50%, but Mucormycosis infection is usually rare [4].
It is observed that, In May 2021, in India health experts believe that the reason for the increase in cases in this way is due to the high incidence of diabetes in Indian patients [5]. This is due to the persons exposure to mucor mold which is commonly found in soil, plants, manure, and decaying fruits and vegetables [6]. Doctors believe that the use of steroids, a life-saving treatment for severe and critically ill Covid-19 patients [3]. On the other hand, steroids reduce inflammation in the lungs for Covid-19 and also, appear to help stop some of the damage that can happen when the body's immune system goes into overdrive to fight off coronavirus. But they also reduce immunity and push up blood sugar levels in both diabetics and non-diabetic Covid-19 patients [3]. On the other hand, Mucormycosis causing symptoms like coughing out blood, blackening over the nose, blurred vision, chest pain, and breathing difficulties [7]. While a classic feature of this infection is tissue necrosis or tissue death. But, if the fungus spreads to the eyes, the patient may develop blurred vision, drooping eyelids, swelling, and possible vision loss [7].

Phylum: Zygomycota
The zygomycetes are facultative saprophytes. They are terrestrial but, some of them are parasites. The hyphae aseptate.
But septa are found in the reproductive structures only [8]. Rhizoids and columella are also occurring.

Asexual reproduction
It takes place by vegetative methods and sporulation. Vegetative reproduction occures by fragmentation, chlamydospore and oidia formation, but it absent in Rhizopus stolonifer [9]. are mature, the intervening fusion septum between them dissolves [9]. The fusing gametangium from of two opposite mating types results in a heterokaryotic zygosporangium. The combined protoplast in the prozygosporangium containing a number of diploid nuclei is called the zygospore [9]. A thick-walled develops that protects the zygospore until environmental conditions become favorable. When conditions are favorable, nuclear fusion (karyogamy) occurs within the zygospore producing diploid nuclei. This is followed by meiosis. The zygospore then germinates to produce a sporangium which releases haploid spores [8].

Zygomycosis
Zygomycosis is referring to infection caused by diagonal of order Mucorales commonly involving rhinocerebral structures and occasionally the lungs, gastrointestinal tract, skin and other organ system [1]. The zygomycosis are all human fungal infections.
Saprophytic diagonal belonging to the genera Rhizopus, Absidia and Mucor [1], by condition that compromise the immune system, particularly diabetes leukemia, lymphomata, prolonged Steroid and antibiotic treatments, organ transplantation, uremia, malnutrition, and general debilitation [1] (Figure 1-7).     drugs ,then the affected tissues become exhausted, as well as the immunity becomes weak, especially in diabetic patients and this helps the secondary opportunistic weak infectious pathogen to grow and infect the same mucous tissues when the environment in which the patient is present is favorable for the growth of the fungus when high humidity and a temperature suitable for its growth, 28 or 37, and possible contamination of hospital equipment. The growth of order Mucorales fungal species is faster in penetrating into the tissues of the body, as it extends from the nose until it infects the eye and then extends to the brain. Its spores can travel in the bloodstream and infect other parts of the body.

Treatment
Once Mucormycosis is suspected, Amphotericin B [1] and [11], at an initial dose of 1mg is initially given slowly over 10-15 minutes into a vein, then given as a once daily dose according to body weight for the next 14 days. It may need to be continued for longer [5], and Isavuconazole and Posaconazole are alternatives also, used [11].