1. E=ⁱ mc² - New Law of Information World

Updated critical review of R. Klimek,s Prevention of Iatrogenic Cervical Cancer (E-ISBN:978-81-970671-3-6),DOI:10.9734/bpi/anums/v8/7319B

Medicine is the most important human domain dealing with theoretical principles how to protect or restore personal health into practice, what was the main subject of the electronic world congress “Biocosmology and Cancer” in Cracow, printed successfully in the electronic journal “Biocosmology and neo-Aristotelism” [2017,7(1,2,3/4) and 8(1,2): 1-262] and based on the video-lectures (http://tiny.pl/gnzdk - K.S. Khroutski, R. Klimek, K. Kratky, X. Liu, J. Bremer, P. Heusser, W. Kofler, J. G. Schenker, P. Karocki), Upon multi years own experiences the authors have summarized the historic discovery of natural thermodynamic cause of cancer and infertility as well as the prevention and psycho-neuroendocrine therapy of all diseases [K.S. Khroutski, R. Klimek Biocosmological definition of information and its naturalist causative significance. Biocosmology - neo-Aristotelism 2018,.8 (2): 204-262; Klimek R.”Psychosomatic aspects of infertility” in: Schenker J.G et al.(eds) Reproductive Medicine for Clinicians. Spinger V. (2017)]. Information is transparent event and therefore for man hidden, but existing in any cosmic being as not visible but potential attribute. It means the act of informing and the action of giving the form to the being, which denotes the entirety of everything that exists in the essential or/and existential sense according to the law E =ⁱ mc²; the equal sign (=) of the quantum feedback equivalence of information, mass and energy denotes mass and energy as quantity equal and at the same time the equation raised to the power of information (=ⁱ) defines the information’s part of reality. Domination of information first of all turns the focus upon the meaning of the moral-ethic dimension of every person to live and work according to her/his autoteleological principle of compatibility between deeds and socially acceptable human values. For example cancers are self-organized from the cells of the patient, who did not provide the necessary conditions for own cellular metabolism. Carcinogenesis consists of natural occurring spontaneous cellular processes which may lead to self-organized dissipative structures of cancers what was first explained in 1977 [2-6]. All oncogenic factors can divide into sufficient or necessary to events for creating a dissipathogenic cellular status quo, which is an alternative of cellular or social death. Neoplasm cell is an effect of carcinogenesis, but not a causal point at which it begins its existence with information law E=ⁱ mc², confimed also at: 1. R Klimek (2015) Psychoneurocybernetic Conquest of Carcinogenesis and Cancers, Nova Biomedical., USA; 2. R Klimek (2019) Information Medicine-E=ⁱ mc² WIU, ISBN 978-83- 923871-5-2, Cracow 2018 and BCnA 2019, 9: 369-492; 3. Klimek R, Tadeusiewicz R, Gralek P (2017) Virtual information links Matter and Energy: E= ⁱ mc², in: Hisaki Hashi (ed.) Philosophy of Nature in Cross-Cultural Dimensions. Dr Kovac Publ., Hamburg. 4. Klimek R (2016) Life, Cancer and Virtual Information, BCnA 6(2): 255 - 272; 5. Klimek R (2023) Law of informational cosmic spacetime: E= ⁱ mc² Adv Theo Comp Phy. 6(3),233-23; 6. Klimek R (2015) Prevention of Iatrogenic Cervical Cancer: A Critical Review,OJOG 5:775-783.         

The universe is a self-realizing informational spacetime, whose quintessence is life, i.e. the informational interchange of mass and energy among directly or indirectly visible its particles. Information is transparent event and therefore for man hidden, but existing in any being among its elements as not visible but potential attribute. Practically everyone can see own silhouette visible in the mirror, which does not contain any single atom of the human body. Combining mass and energy with information in the inseparable quantum equivalence of E= ⁱ mc² has opened a new informational medicine to give doctors knowledge for their medical practice to help patients maintain truth, good health, and beauty. In the theory of cosmic existence, the steady growth of civilization and its associated diseases worldwide can be returned to the natural beginning of a man's individual life when the concept of matter will be replaced with information, to which energy and mass belong! Technological advances have enabled us to use modern tools to indicate the location and concentration of substances in selected parts of the human body. The Nuclear Magnetic Resonance Imaging method involves atom nuclei's excitation and analyzes how these nuclei recover to the original equilibrium to generate tomographic images in any plane for imagining diagnosis in modern medicine. The essence and existence of information rays and patterns (fields) may be proved by human sight's nature, e.g., using the mirror at which everybody looks every day. A mirrored picture does not contain any single atom of the natural person because it appears thanks to resonating informational field (“pattern information”), wherein the information rays coming from a real object and from eyes (sight's rays) meet together and resonance due to having the identical value of their unique character. Also, the mechanism of creation the silhouette of a crucified man based on a three-dimensional image placed on a heavy canvas could be understood in terms of quantum equivalence of information, mass, and energy E = ⁱ mc² (Klimek R. Socratic Dialogue: Man's self-portrait image on Turin Shroud. BCnA:10(1&2)2020;299-310). Similarly, R. Tadeusiewicz (Place and Role of Intelligent Systems in Computer Science. Computer Methods in Materials Science. 2010; 10:193-206) described cognitive systems as a new dimension of economic informatics. using mathematical linguistics. Language consists of several elements (words and grammatical rules) that can cause infinite possible meanings. For example, infertility and cancers pertain to natural phenomena in contrast to common belief about their dramatic meaning because they safeguard the existence and development of the genus Homo sapiens through the selective elimination of sick individuals least suited to the human species and environment. Based upon multi years own experiences in conservative, surgical, thermo- and radio-therapy of neoplasms the physicians have evidence that ACTH-depot therapy, oxytocinase monitoring of pregnancy and ultrasonography prognosis of expected birth date with accuracy of ±3 days instead ±3 weeks are at least three main medical interventions to reduce the rate of miscarriages, preterm births and in consequence of cervical cancers. Cancer cells are signals on the last human way to die and therefore man should try to treat the carcinogenesis instead to cure only the cancer diseases, because first cancer cell is foreboding of insufficiency of organism self-control to exist. In treating neoplasms doctors use scalpels, lasers, radioactive radiation and even poisons as effective tools, part of which is also language, made up of words, which are understandable by patients. A special place is taken by heredity and the upbringing of a person, who, due to his free will, lives according to his own auto-teleological values and rules of social life. Until the creation of the concept of generative entropy it was difficult to distinguish the necessary conditions from the sufficient cause of self-organization of neoplasms from the cells of the ill or only ageing patient. Modern conquest of carcinogenesis and cancers is the result of international uninterrupted cooperation since the our neurohormonal symposium entitled “Oxytocin and its analogues” in Cracow 1964. Many P.T. Scientists contributed to discovery of natural cause of cancer, mathematical interpretation of its cause as well as to obstetrical prevention of all human cancers and psycho-neuro-endocrine therapy of diseases. The dissipative nature of cancers has to be presented so that everyone could understand the neoplastic diseases and the primary significance of own life style in the formation and progress of cancer along with importance of caring about the environment inhabited by people.

2. Comments on the Klimek’s Informational Law: E = ⁱ mc²

Włodzimierz Korohoda*

*Corresponding author: Professor, Department of Cell Biology, J. Zurzycki Institute of Molecular Biology, Jagiellonian University, Kraków, Poland.

Opinion

A review on informational spacetime world and cancer by Rudolf Klimek is based on over 50 years of clinical experience of the Author as biochemist, gynecologist, obstetrician and endocrinologist, but not limited to practical clinical medicine. His broad interest in cancer and general problems related to medicine and philosophy of science resulted in numerous books and articles, some of them with me as co-author [ Klimek R (2023) Law of informational cosmic spacetime: E= ⁱ mc² Adv Theo Comp Phy. 6(3),233-23; Klimek R (2024) Prevention of Iatrogenic Cervical Cancer: A Critical Review-E-ISBN: 978-81-970671-3-6; Klimek R. (2024) E= ⁱ mc² - New Law of Informational Space - Time World. Am J. Biomed Sci & Res. 21(1)55-56]. Concepts of Klimek are considered by some scientists to be controversial. They are, however, very inspiring for scientists carrying on research related to cancer and human physiology. As cell biologist I am interested in cell biology including cancer cell biology. I would like to add here a few remarks to problems discussed in this review. Much of the basic information about neoplastic diseases is due to research conducted on normal and cancerous animal and human cells. Cancer is not only found in human organisms. Almost all vertebrates suffer from it: fishes, amphibians, reptiles, birds and mammals. Not only medicine doctors, but also biologists carry on research on its nature, both on whole animal organisms and on cells in cultures in vitro The neoplastic diseases occur in all organs and all types of cells. They can be induced by great number of various factors, such as viruses, free radicals, variety of organic and inorganic substances, X rays, or can appear spontaneously without any defined cause. For such a great diversity of cancer diseases and their inducers it is difficult to identify common features and to find effective treatment. Klimek already in 1977 suggested that the common feature of all cancers is the energy dissipation. He has been one of the first scientists who put forward the idea postulating that the information is besides mass and energy a third basal entity in universe. This concept is in last years propagated by increasing number of scientists; kosmologists philosophers and physicists. Klimek in his articles discusses the significance of preventing the development of cancer as a disease. Also Djamgoz and Plant [2014] in the book “Beat Cancer’ concentrate attention on fac-tors which prevent and slow down development of cancer.

The results of studies performed on cancers transplantable in experimental animals and tissue cultures of the cancer cells in the second half of XX century have greatly improved effectiveness diagnosis and treatment of cancer patients. Scientists got the possibility to follow and influence the development of cancer in animals. It was proved that single cell {as in leukemia L 12) or a few cells Walker or Ehrich ascites cancers, can cause development of cancers lethal for animals. Observations on cells in vitro permitted to identify many differences between cancer and normal cells. The time-lapse technique to follow cell behavior during neoplastic transformation helped to find features differing between cancer and normal cells. It became possible to identify numerous different factors which are able to cause the transformation of individual cells which introduced to animals develop lethal cancers. This activity was observed with viruses [polyoma], mutations of genes of tyrosine kinase, free radicals, irradiation with X rays, and many organic and inorganic substances, which appeared to be cancerogenic. Such results of experiments performed under controlled conditions help to avoid in human surrounding the cancer inducing factors which induce inheritable changes this is neoplastic cell transformation. (i) Also factors which cause promotion in already transformed cells [their proliferation (ii) and cause the increased malignancy [progression] in cancer cell heterogenous populations in tumors (iii). These three stages in development of cancer are eases in animals were found to be dependent on different factors and require separate ways of recognition and prevention.

The research on cancer origin, treatment and prevention carried on in experimental laboratories are complementary to observations and studies under clinical conditions. Some of results of experimental studies became effectively introduced to clinical oncology, but many results still wait for decades after their description. Another insufficiently studies are the effects of enhancement of cancer development by factors which acting together are much more effective than when acting separately. Such enhancement is recognized by asbestos and cigarette smoking. The phenomenon is similar as more effective curation of cancer by the sets of cytostatic than when applied each separately. The effective prevention of cancer diseases strongly stressed by Klimek should be more generally examined in both induction and treatment of cancer diseases. Very early it was recognized that croton oil, which itself is not cancerogenic-is the factor which strongly induces cancer promotion and progression and hence development cancer diseases. Klimek in his review documents effects of obesity and papilloma viruses’ infections on cancer diseases in woman. Prevention of cancer disease occurrence by elimination of factors which themselves do not induce cancer but influence its promotion and progression should be more intensively investigated.

It was observed already more than half hundred years ago that cell and animal nutrition have very significant influence upon the induction, promotion and progression of cancer diseases but now it is confirmed by clinical medicine. The significance of nutrition upon cancer occurrence by its prevention and acceleration in human populations remains to be more broadly studied and recognized. Already this problem consideration would require a separate extensive review of literature concerning experimental and clinical observations. Years ago it was shown that the changes in electric features of cell surfaces which accompany cell neoplastic transformation and malignancy. More recently the close correlation between electrophoretic mobility, electrokinetic potential and capacity to form metastases has been demonstrated. These results have not been applied to clinical diagnosis of cancer malignancy because the measurements with microscopic single cell electrophore-sis are time-consuming and required specialized equipment. Now such measurements can be accomplished in a few hours instead of months, but this demands co-operation of cell biology specialists with clinical oncology doctors. Rather seldom in lucky circumstances the discoveries from basic research of cells are relatively fast, in a few years, applied to clinics. Such fast usage of studies of intermediate filaments [11nm in diameter] which permitted to demonstrate cell and tissue type specific chemical nature of intermediate filaments [ research of W. Franke in Heidelberg and Mary Osborn and K. Weber in Goetingen became confirmed by pathologists J. Stachura in Kraków and W. Domagała in Szczecin]. This permitted to discriminate secondary cancers from primary tumors in clinical patients and to identify the primary tumor localization.

Very inspiring for new studies in oncology are Klimek’s concepts, presented earlier in his books and articles in which he discusses this concept of information as third cosmic being besides the matter and energy. This idea is now often discussed by cosmologists and physicists, and Klimek was one of the first who formulated this hypothesis. The examination of this theory in biology and oncology can be very important everywhere where the genetic information is investigated. This problems got basic significance for attempts to explain the phenomenon of life of organisms but also for analysis of molecular and cellular backgrounds of initiation, promotion and progression of cancer diseases. The new discoveries in cell and molecular biology cause the necessity of correction of many basic concepts, considered for decades as proved; First of all the results of epigenetic demonstrated the heritage of new form on the cellular level. Only partly true are the postulates that only mutations, this is changes in genome can lead to permanent new features in cells. The cell differentiation was found to be associated with selective gen regulation and not changes in genes. The permanent and heritable changes associated with the genes are not necessary {though often well documented] for initiation of neoplastic transformation in single cells. Also promotion and progression of malignancy in developing cancer can be associated with epigenetic and not necessary with genetic changes. Genetic information in living organisms is carried in nucleic acids {DNA and RNA] in genes and their structure but also in their arrangement and selective activation and inhibition. All cells in a multicellular organism in spite of their structural and functional versality are carriers of the same genetic information as zygote, the one cell from which they all origin. It requires investigation how epigenetic changes in cell features can be responsible for initiation, promotion, and progression of neoplastic diseases, similarly as permanent changes in structure and function of differentiating cells. The identification and elimination of factors which do not induce but effectively intensify promotion and progression of already transformed cells and cancer genesis should be more extensively studied to prevent spreading of cancer diseases.

In summary. The review by Klimek concerning literature on women’s cancers prevention and treatment discusses problems common to almost all cancer diseases. He concentrates on effective prevention of cervical cancer not only by elimination of HPV virus¬es and obesity, but his comments postulate more broad research of promotion and progression factors besides metagenes and direct cancerogens. The research based on epigenetics and recognition of genetic information and its realization requires analysis of epi¬genetic heritable changes involved in progression of cancer malig-nancy and development of diseases. Taking into account these new aspects of oncology should inspire numerous new directions of examination and analysis of cancers origin and development. The review and these short comments show the need for more exten¬sive and broad discussions of biological aspects of cancers, based on results of information biology development in 21^st century.

Prof. Rudolf Klimek

Professor ord., Dr h.c.multi, born 1932 Cracow, Poland, emeritus ordinary professor of Jagiellonian University Cracow, president of World Information University, author of over 760 publications and 75 books: discovery of sulfur bacteria cytochrome S (co-author)-1954, introduction of hypothalamic hormones in medicine and synthetic ACTH in obstetrics-1960, enzymatic monitoring of pregnancy and delivery-1960, description of hypothalamic post-pregnancy syndrome and reactions of cervical vessels in precancerous and cancerous stages-1963, discovery of natural thermodynamic cause of cancers as dissipative structures-1977 and thermodynamic theory of health and disease-1978, introduction the nuclear magnetic resonance imaging in clnical practice-1980, immunotherapy of cervical intraepithelial neoplasia-1985, and the formulation of law equation E=imc2 of the threefold mass-information-energetic universe - 2014, mirror experiment of existence of bidirectional cosmic informational rays - 2017, solution of Turin Shroud mystery mechanism of man's image - 2018. Information has been equated to the quantum equivalence of mass and energy, expressed through the feedback equation E=imc2. This approach provides a methodological foundation for understanding the meaning and role of information as a causal factor, encompassing both the static and dynamic development of the universe as an informational whole. Information in addition to its many excisting features has an atribute of polymorfism and may exist in many different forms yet retaining its identity even though it may be expressed in different ways.

Philosophy of cosmic being promotes the information medicine so that everyone could understand the primary significance of own and social human health along with importance of caring about the world inhabited by people. A lot of information is passed on as true and correct, but not always is known who has created it and for what reason. M.Vopson proposed the experiment capable of measuring the mass of digital information, which consists of an ultra accurate mass measurement of a data storage device when all its memory bits are in fully erased state and then followed by the operation of recording digital data on all of its memory bits until is at full capacity. He argued that information is a distinct form of matter, or the fifth state, along the other four observable solid, liquid, gas, and plasma states of matter. He expected that his work will stimulate further theoretical and experimental research, bringing the scientific community one-step closer to understanding the abstract nature of matter, dark matter, energy and information in the Universe.

References

• R Klimek (2015) Psych neurocybernetic Conquest of Carcinogenesis and Cancers, Nova Biomedical.
• R Klimek (2019) Information Medicine-E=ⁱ mc² WIU, ISBN 978-83-923871-5-2, Cracow 2018 and BCnA 2019, 9: 369-492.
• Klimek R (1990) Conquering cancer ourselves. New trends in gynecology and obstetrics. 6(2): 53-117.
• Klimek R, Tadeusiewicz R, Gralek P (2017) Virtual information links Matter and Energy: E=ⁱ mc², in: Hisaki Hashi (ed.) Philosophy of Nature in Cross-Cultural Dimensions. Dr Kovac Publ., Hamburg.
• Klimek R, Lauterbur PC, Mendonca Dias MH (1981) A discussion of nuclear magnetic resonance (NMR) relaxation time of tumors in terms of their interpretation as self-organising dissipative structures and of their study in vivo by NMR zeugmatographic imaging. Gin. Pol 52(6): 493-502.
• Klimek R, Lauterbur PC, Mendonca Dias MH (1983) A discussion of nuclear magnetic resonance (NMR) relaxation time of tumors in terms of their interpretation as self-organising dissipative structures and of their study in vivo by NMR zeugmatographic imaging. Materia Medica Polona 15(1-2): 47-53.
• Klimek R (2014) Threefold material-informational-energetic reality: E=ⁱ,mc², Bio cosmology - Neo-Arisotelism 4(4): 405-415.
• Klimek R (2016) Life, Cancer and Virtual Information, BCnA 6(2): 255-272.
• KS Khroutski, R Klimek (2018) Biocosmological definition of information and its naturalist causal significance. BCnA 8(2): 204-262.
• M Vopson (2019) The mass-energy-information equvalence principle. AIP Advances 9(9): 095206.