Volume 21 - Issue 1

Case Report Biomedical Science and Research Biomedical Science and Research CC by Creative Commons, CC-BY

Fahr’s Disease Presenting as Primary Progressive Aphasia

*Corresponding author: 4Director of Clinical Neurophysiology Laboratory, Neurology Professor, UCF Medical School, USA.

Received: December 14, 2024; Published: January 03, 2024

DOI: 10.34297/AJBSR.2024.21.002791

Keywords: Fahr, Progressive, Aphasia

Case Report

A 66 years-old-man presented with progressive word-finding difficulties and impulsive behavior. Examination showed nonfluent aphasia, anomia, impulse control disorder, executive dysfunction and ataxia. Neuropsychological testing was consistent with primary progressive aphasia. Labs were unremarkable, including parathyroid hormone, calcium, and phosphorus. CT head showed symmetric calcifications in basal ganglia, thalamus and cerebellum (Figure 1 A, B, C). Brain PET was normal. Fahr’s disease also known as an idiopathic basal ganglia calcification may have genetic, infectious, metabolic etiology and typically presents with movement disorders. Dysarthria is common, but aphasia has not been reported. 1,2 This unusual clinical presentation is likely secondary to the involvement of frontal projections [1,2].

Biomedical Science &, Research

Figure 1: A, B, C. Axial head CT without contrast shows extensive, but symmetric brain calcifications.

Study funding

No targeted funding reported.


The authors report no disclosures relevant to the manuscript.



Conflict of Interests



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